Philosophy of Care
Undergoing radiation treatments can be scary and overwhelming. Each patient has a unique situation involving their specific diagnosis and the treatment of their disease. It is important to recognize the patient’s unique issues in order to provide care for the patient as a whole person. It is also important to help patients understand their diagnosis so that they can make more informed decisions and understand their care.
Dr. Fragoso's main clinical activities involve the treatment of both benign and malignant central nervous tumors that can arise in the adult and pediatric populations. Radiation treatment techniques include Gamma Knife radiosurgery and fractionated radiation radiotherapy (3D or IMRT). Medical interests revolve around the better understanding of gliomas, particularly high grade gliomas.
Glioblastoma multiforme (GBM), a WHO grade IV glioma, carries a poor prognosis for which there have been modest therapeutic advances. My area of interest and research is focused on targeting specific cancer cells that are thought to perpetuate the tumor within the GBM itself. These "cancer stem cells" tend to be resistant to treatment. We are studying ways in which these cells can be targeted specifically and destroyed.
M.D., Harvard Medical School, Boston MA 2004
Ph.D., Harvard Medical School, Boston MA 2004
B.A., Princeton University, Princeton NJ 1992
Internship: Internal Medicine, Morristown Memorial Hospital, Morristown NJ 2005
Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia PA 2009
American Board of Radiology,
American Association of Cancer Research
American College of Radiation Oncology
American Society of Therapeutic Radiology and Oncology
Select Recent Publications
Chen H, Nguyen KNB, Huang H, Feng C, Zhao X, Daly ME, Rao S, Fragoso R, Valicenti R, Sekhon S, Navarro SM, Kim EJ, Cho M, Tam K, Farkas L, Halabi WJ, Monjazeb AM, Rong Y. Effect and Safety of Radiation Therapy Boost to Extramesorectal Lymph Nodes in Rectal Cancer. Pract Radiat Oncol. 2020 Sep-Oct;10(5):e372-e377. doi:10.1016/j.prro.2019.12.007. Epub 2019 Dec 20. PMID:31866577.
Xie B, Zhang L, Hu W, Fan M, Jiang N, Duan Y, Jing D, Xiao W, Fragoso RC, Lam KS, Sun LQ, Li JJ. Dual blockage of STAT3 and ERK1/2 eliminates radioresistant GBM cells. Redox Biol. 2019 Jun;24:101189. doi:10.1016/j.redox.2019.101189. Epub 2019 Apr 9. PMID:30986607.
McGee HM, Daly ME, Azghadi S, Stewart SL, Oesterich L, Schlom J, Donahue R, Schoenfeld JD, Chen Q, Rao S, Fragoso RC, Valicenti RK, Canter RJ, Maverakis EM, Murphy WJ, Kelly K, Monjazeb AM. Stereotactic Ablative Radiation Therapy Induces Systemic Differences in Peripheral Blood Immunophenotype Dependent on Irradiated Site. Int J Radiat Oncol Biol Phys. 2018 Aug 1;101(5):1259-1270. doi:10.1016/j.ijrobp.2018.04.038. Epub 2018 Apr 22. PMID:29891204.
Hartl BA, Ma HSW, Sridharan S, Hansen KS, Kent MS, Gorin F, Fragoso RC, Marcu L. Label-free fluorescence lifetime spectroscopy detects radiation-induced necrotic changes in live brain in real-time. Biomed Opt Express. 2018 Jul 5;9(8):3559-3580. doi:10.1364/BOE.9.003559. eCollection 2018 Aug 1. PMID:30338140.
Yuan Z, Nair CK, Benedict SH, Valicenti RK, Rao S, Fragoso RC, Wright C, Qiu J, Rong Y. Converting Treatment Plans From Helical Tomotherapy to L-Shape Linac: Clinical Workflow and Dosimetric Evaluation. Technol Cancer Res Treat. 2018 Jan 1;17:1533033818785279. doi:10.1177/1533033818785279. PMID:29986638.
Hartl BA, Ma HSW, Hansen KS, Perks J, Kent MS, Fragoso RC, Marcu L. The effect of radiation dose on the onset and progression of radiation-induced brain necrosis in the rat model. Int J Radiat Biol. 2017 Jul;93(7):676-682. doi:10.1080/09553002.2017.1297902. Epub 2017 Mar 17. PMID:28306402.
Yoshida E, Aouad R, Fragoso R, Farwell DG, Gandour-Edwards R, Donald PJ, Chen AM. Improved clinical outcomes with multi-modality therapy for sinonasal undifferentiated carcinoma of the head and neck. Am J Otolaryngol. 2013 Nov-Dec;34(6):658-63. doi:10.1016/j.amjoto.2013.06.005. Epub 2013 Aug 29. PMID:23993024.
Shen X, Andrews DW, Sergott RC, Evans JJ, Curran WJ, Machtay M, Fragoso R, Eldredge H, Champ CE, Witek M, Mishra MV, Dicker AP, Werner-Wasik M. Fractionated stereotactic radiation therapy improves cranial neuropathies in patients with skull base meningiomas: a retrospective cohort study. Radiat Oncol. 2012 Dec 28;7:225. doi:10.1186/1748-717X-7-225. PMID:23270432.
Donaldson JM, Kari C, Fragoso RC, Rodeck U, Williams JC. Design and development of masked therapeutic antibodies to limit off-target effects: Application to anti-EGFR antibodies. Cancer Biol Ther. 2009 Nov;8(22):2147-52. doi:10.4161/cbt.8.22.9765. Epub 2009 Nov 7. PMID:19783899.
Fragoso RC, Pyarajan S, Irie HY, Burakoff SJ. A CD8/Lck transgene is able to drive thymocyte differentiation. J Immunol. 2006 Nov 1;177(9):6007-17. doi:10.4049/jimmunol.177.9.6007. PMID:17056525.